Interleukin 18 in the CNS
نویسندگان
چکیده
منابع مشابه
The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18.
Inflammation is increasingly recognized as an important contributor to a host of CNS disorders; however, its regulation in the brain is not well delineated. Nucleotide-binding domain, leucine-rich repeat, pyrin domain containing 3 (NLRP3) is a key component of the inflammasome complex, which also includes ASC (apoptotic speck-containing protein with a card) and procaspase-1. Inflammasome format...
متن کاملInterleukin 18
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. IL-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers, and in the context of numerous infectious diseases. This short review will describe the basic biology of IL-18 and thereafte...
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A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of the IL1 receptor type II. However, unlike so...
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1Curriculum in Neurobiology and the University of North Carolina Neuroscience Center, 2Department of Pathology and Laboratory Medicine, and 3Department of Microbiology and Immunology, and the Program of Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, North Carolina 27599, and 4Department of Internal Medicine and Howard Hughes Medical Institute, Washington Univers...
متن کاملInterleukin-18 and IL-18 Binding Protein
Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1β, IL-18 is synthesized as an inactive precursor requiring processing by caspase-1 into an active cytokine but unlike IL-1β, the IL-18 precursor is constitutively present in nearly all cells in healthy humans and animals. The activity of IL-18 is balanced by the presence of a high affinity, naturally occurring IL...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2010
ISSN: 1742-2094
DOI: 10.1186/1742-2094-7-9